What are clinical trials?
Clinical trials at the OVC HSC are research studies involving client-owned animals with the ultimate goal of advancing animal health care. These studies may try to identify the most effective therapies and practices for a given condition or increase our understanding of a disease process.
Participation in clinical trials at OVC HSC may provide our clients & their companion animals with unique access to new tools and treatments. Clinical research in companion animals may also help humans and vice versa.
For all clinical trials performed at the Ontario Veterinary College, informed consent will be obtained from a patient’s owner. The clinical care of a patient will not be compromised regardless of participation status.
OVC HSC is the first Canadian centre in the Comparative Oncology Trials Consortium (COTC – 20 sites) of the NIH-NCI-Center for Cancer Research’s Comparative Oncology Program set up to conduct clinical trials in dogs with cancer to assess novel therapies! We currently do not have any active studies with the COTC.
Recruitment closed in Nov 2017 for the first study: Standard of Care Therapy with or without Rapamycin in Newly Diagnosed Dogs with Appendicular Osteosarcoma).
Our second trial in collaboration with NIH-NCI-COTC recently closed for recruitment (Oct 2019): Evaluation of a recombinant, attenuated Listeria monocytogenes expressing a chimeric human HER2/neu protein in dogs with osteosarcoma in the adjuvant setting.
For information on oncology & oncology-related clinical trials currently recruiting companion animal patients at the Ontario Veterinary College, please refer to the links below:
General Oncology Studies
- **ON HOLD**Collection of Samples from Dogs Diagnosed with Cancer and Not Scheduled to Undergo Surgery for Tumour Removal
- **ON HOLD**Collection of Biological Specimens from Dogs Scheduled for Biopsy or Surgery for Suspected or Known Cancer
- **STARTING SOON** Pilot evaluation of near infrared fluorescence imaging for intraoperative identification of canine pancreatic tumours and metastasis (ICG)
- **ON HOLD** Profiling and validation of extracellular vesicles as circulating biomarkers in canine OSTEOSARCOMA: a DOGBONe project
Head & Neck
- Evaluation of agreement between computed tomography lymphangiography and the combination of methylene blue and indocyanine green for sentinel lymph node mapping in dogs with oral tumours
- Evaluation of regional lymph node metastasis in canine thyroid carcinoma
Lymphoma & Leukemia
- Acute Myeloid Leukemia Study
- Characterization of Innate Lymphoid Cells in Canine Blood
- **ON HOLD**Identification of response to chemotherapy in relapsed canine lymphoma patients
- Prognostication of canine T-cell lymphoma
Skin & Subcutaneous Tumours:
Mast Cell Tumours
Soft Tissue Sarcomas
- **ON HOLD** Investigating biomarkers for metronomic cyclophosphamide treatment of canine soft tissue sarcoma
- **NEW** Evaluation of sentinel lymph node mapping in dogs with LUNG TUMOURS using CT lymphography and intraoperative indocyanine green.
- Bladder microbiome in female cats & dogs
- Feline acute kidney injury study
- **ON HOLD** Comparison of subcutaneous hydromorphone delivered with Medipacs Mini-InfuserTM CRI pump to subcutaneous intermittent injection in dogs
For further information on current and upcoming clinical trials please contact:
Vicky Sabine (PhD), Clinical Research Co-ordinator
Work cell #: 226-218-0338
Email address: firstname.lastname@example.org
Associated Links Out:
- OVC Pet Trust – Help the pets we love, live longer, healthier lives! OVC Pet Trust is Canada’s first charitable fund dedicated to the health and well-being of companion animals.
- Kennel to Cure – A research collective based at the OVC with collaborators and team members across Canada, focused on translational research between companion animal cancer research and human cancer research. Research focuses include pathobiology of tumourigenesis, novel therapeutics and personalized medicine, ethics and quality of life, and social, economic and logistical aspects of cancer search in Canada.
- Smiling Blue Skies – A broad scope support and resource page for all things about canine cancer, its treatment, and research. Smiling Blue Skies can offer financial support for treating pets with cancer.