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Prognostication of Canine T-Cell Lymphoma

Associated Publication:
Deravi, N., Berke, O., Woods, J. P., & Bienzle, D. (2017). Specific immunotypes of canine T cell lymphoma are associated with different outcomes. Veterinary immunology and immunopathology191, 5–13. https://doi.org/10.1016/j.vetimm.2017.07.008
https://pubmed.ncbi.nlm.nih.gov/28895866/

Objective:

To improve diagnosis and provide a more accurate prognosis for T-cell lymphomas

Background:

T-cell lymphomas are generally considered to have a worse prognosis than B-cell lymphomas.  However, within the large group of T-cell lymphomas there are some that progress quickly and some that progress slowly.  We currently do not have good methods for differentiating these subtypes of T-cell lymphoma.

Study design:

A lymph node aspirate will be analyzed by flow cytometry to determine if the dog has B- or T-cell lymphoma. If the dog has a T-cell lymphoma, an enlarged lymph node will be removed under general or local anesthesia for histopathology.

Inclusion criteria:  

We are enrolling dogs with a cytology or histopathology diagnosis of lymphoma who will be treated with chemotherapy.

Exclusion criteria:

  • Treatment with chemotherapy or glucocorticoids before referral to OVC.

Samples required:  

  • Biopsies and blood samples (~5ml) before and after 4 weeks of treatment

Client Compensation:              

  • The study will cover the cost of flow cytometry and lymph node removal.          

Researchers:

  • Dr. Dorothee Bienzele (PI)
  • Dr. Nariman Deravi

Contact: 

Vicky Sabine (PhD), Clinical Research Coordinator

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