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Evaluating the Clinical Outcome of Dogs Diagnosed with T-cell Lymphoma

Associated Publication:
Deravi, N., Berke, O., Woods, J. P., & Bienzle, D. (2017). Specific immunotypes of canine T cell lymphoma are associated with different outcomes. Veterinary immunology and immunopathology191, 5–13.


To improve diagnosis and provide a more accurate prognosis for T-cell lymphomas


T-cell lymphomas are generally considered to have a worse prognosis than B-cell lymphomas.  However, within the large group of T-cell lymphomas there are some that progress quickly and some that progress slowly.  We currently do not have good methods for differentiating these subtypes of T-cell lymphoma.

Study design:

A lymph node aspirate will be analyzed by flow cytometry to determine if the dog has B- or T-cell lymphoma. If the dog has a T-cell lymphoma, an enlarged lymph node will be biopsied under sedation for histopathology.

Inclusion criteria:  

We are enrolling dogs with a cytology or histopathology diagnosis of T-cell lymphoma who will be treated with chemotherapy.

Exclusion criteria:

  • Treatment with chemotherapy or glucocorticoids before referral to OVC.

Samples required:  

  • Biopsies and blood samples (~5ml) before starting chemotherapy treatment.

Client Compensation:              

  • The study will cover the cost of flow cytometry and lymph node biopsy.          


  • Dr. Dorothee Bienzele (PI)


Vicky Sabine (PhD), Clinical Research Coordinator

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